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As shown in Figure 1 (A), an upregulation of GST gene expression in the gut of zebrafish was observed at 40 and 60 d and it was induced up to 10-fold and 9-fold, respectively, in wPE microplastic exposed male zebrafish when compared with the respective control group

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61,62,63 CDO is highly regulated at the level of protein turnover, as oxidative degradation of cysteine by CDO is highly inducible, 64 and high cysteine levels inhibit CDO ubiquitinylation and reduce its proteasomal degradation

GLP-1 RAs consistently improved composite (secondary) renal outcomes in the CVOTs, principally driven by a reduction in new-onset albuminuria